The Precision of Progress: Understanding Targeted Therapy in Hematology
Targeted therapy is a form of Biological Therapy for Cancer that specifically targets genes, proteins, or molecules that help cancer cells grow. This precision-based approach minimizes damage to healthy cells and reduces side effects. A hematologist or blood cancer specialist administers these therapies for Malignant Blood Diseases.
Dr. Nishad Dhakate: A Leading Expert in Hematology and BMT
Dr. Nishad Dhakate specializes in autologous and allogeneic blood and bone marrow transplants, leukemia, lymphoma, and myeloma. He expertly manages inherited and acquired red, white, and platelet disorders, as well as immunodeficiency disorders, with individualized care.
Symptoms and When Targeted Therapy is Used
- Symptoms: Persistent fatigue (Anemia), frequent infections (Immunodeficiency), or Bleeding Disorder (Thrombocytopenia) may indicate advanced blood cancer.
- Causes and Indications: Prescribed based on genetic mutations or protein overexpression in cancer cells. Highly effective for Chronic Myeloid Leukemia (BCR-ABL fusion gene), certain Leukemia subtypes, Hodgkin’s Lymphoma, Non-Hodgkin’s Lymphoma, and Myeloma. Can be primary therapy or combined with other treatments.
The Procedure: A Closer Look at Precision Medicine
- Molecular Testing: Patient’s cancer cells are tested for genetic mutations or molecular targets, often using a bone marrow or blood sample.
- Treatment Administration: Targeted drugs bind to specific cancer molecules, blocking growth signals or marking the cells for immune destruction. Administered orally (pills) or via IV infusion.
- Monitoring: Regular blood tests and, occasionally, follow-up bone marrow biopsies monitor response and remission status.
Targeted therapy is precise, leading to fewer severe side effects like hair loss or nausea, though side effects can still occur and are managed by the hematology doctor.
Frequently Asked Questions (FAQs)
Que. Is targeted therapy a cure for cancer?A. For some blood cancers like Chronic Myeloid Leukemia, targeted therapy can achieve long-term remission and transform a previously fatal illness into a manageable chronic condition, though it may not be a complete cure. Que. What is the difference between targeted therapy and CAR-T cell therapy?
A. Both are forms of immunotherapy but differ in approach. Targeted therapy uses drugs to block specific molecules on cancer cells, while CAR-T cell therapy modifies a patient’s T-cells to attack cancer. Que. Can targeted therapy be used with a bone marrow transplant?
A. Yes. Targeted therapy can be used before a transplant to achieve remission or after to prevent relapse. Que. Can targeted therapy treat a coagulation disorder?
A. No. Targeted therapies are not designed for coagulation disorders like Deep Vein Thrombosis, which require specific Coagulation Tests and medications.
